Francesco Negro is Professor at the Departments of Specialty Medicine and of Pathology and Immunology of the University of Geneva, Switzerland. He is also Founder and Chairman of the Swiss Hepatitis C Cohort Study, and Educational Councilor of the European Association for the Study of the Liver. Professor Negro earned his medical degree in 1982 and was board-certified in Gastroenterology in 1986 at the University of Torino, Italy. He undertook post-doctoral training at the Division of Molecular Virology and Immunology, Georgetown University, USA, and at the Hepatitis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA, between 1986 and 1989. Professor Negro analysed hepatitis C virus (HCV) replication at the tissue level using several distinct approaches, establishing anatomo-clinical correlations. His studies led him to associate HCV genotype 3a with a particular form of severe liver steatosis, and to analyse the mechanisms thereof. More recently, Professor Negro’s work has focused on the pathogenesis of extrahepatic manifestations associated with HCV, and, particularly, on the mechanisms leading to glucose metabolism alterations, such as insulin resistance and diabetes, and on the epidemiology of HCV. He has participated in several clinical trials in acute and chronic HCV and has authored or co-authored more than 270 peer-reviewed manuscripts in the field of hepatology.